"Therapeutic" serum concentration of phenytoin: the influence of seizure type.
نویسندگان
چکیده
Serum phenytoin concentrations were monitored prospectively in 26 patients with previously untreated partial epilepsy, during monotherapy with phenytoin. Only six remained entirely seizure-free, although only four experienced further tonic-clonic seizures. There was no correlation between serum phenytoin concentrations and freedom from partial seizures in those patients in whom such seizures recurred. There did appear to be a correlation between serum phenytoin concentration and freedom from tonic-clonic seizures.
منابع مشابه
مقایسهی سطح سرمی فنوباربیتال و فنیتوئین بین کودکان مبتلا به صرع پایدار و صرع پایدار مقاوم
Background & objective: Due to high kinetic variation of antiepileptic medications in children, judgment on the efficacy of intravenous phenytoin and phenobarbital in treatment of refractory status epilepsy, requires measurement of serum levels of the drugs. The aim of this study was determine and compare serum levels of phenytoin and phenobarbital, as the two major and common first- line drugs...
متن کاملDETERMINATION OF PHA RMACOKINETIC PARAMETERS OF PHENYTOIN IN IRANIAN EPILEPTIC PATIENTS
Adjustment of phenytoin dosage in patients is very difficult due to its nonlinear metabolism and patient to patient variation in its kinetics. It has been recommended that the dosage of phenytoin should be adjusted according to its plasma concentration and requirements of the patients. Therefore, the present study was carried out to identify the various factors which may influence the plas...
متن کاملN-octyl-modified magnetite NPs for optimization of solid phase extraction for trace analysis of phenytoin in real samples
objective: Phenytoin is an anti-seizure medication used to treat epilepsy, as well as to control arrhythmias (irregular heartbeat) and to treat migraine headaches and nerve pain. It is recommended to determine the amount of this drug in the blood to control the seizure and prevent its toxicity. In the present study, a sensitive and simple procedure based on the dispersive solid phase extraction...
متن کاملComparing paediatric intravenous phenytoin doses using physiologically based pharmacokinetic (PBPK) modelling software
PURPOSE To use a physiologically based pharmacokinetic (PBPK) modelling system to predict the serum levels achieved by two different intravenous loading doses of phenytoin. METHODS A phenytoin pharmacokinetic model was used in the Simcyp population-based ADME simulator, simulating 100 children age 2-10 years receiving intravenous phenytoin (18 and 20mg/kg). Visual checks were used to evaluate...
متن کاملProblems with phenytoin administration in neurology/neurosurgery ITU patients receiving enteral feeding
Our objective was to investigate the relationship between phenytoin bioavailability, enteral feeding and serum albumin levels in patients admitted to neurology/neurosurgery ITU, via case studies of three patients. The research was performed at the Walton centre for Neurology and Neurosurgery NHS Trust, Liverpool, England, and our subjects consisted of three cases admitted to ITU (1 status epile...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of neurology, neurosurgery, and psychiatry
دوره 47 3 شماره
صفحات -
تاریخ انتشار 1984